Uploaded and Shared in Youtube by: USFoodandDrugAdmin The Institute for Safe Medication Practices (ISMP) recently cited a report from the ISMP Canada Safety Bulletin about the death of a patient who was accidentally injected with topical epinephrine. The attending surgeon and nurse mistakenly thought the syringe they were using contained lidocaine with epinephrine 1:100,000. ISMP noted an earlier case in which a child died from cardiac arrest after his ear was infiltrated with a syringe containing epinephrine 1:1,000 that had been filled from an open cup. The physician mistakenly assumed that the solution in the cup contained lidocaine with epinephrine 1:100,000. ISMP recommends several steps that can help prevent fatal accidents of this kind, including: •Supply epinephrine for topical use in a pour-bottle so that it is not likely to be injected. If these bottles are not available from the manufacturer, require the pharmacy to prepare ready-to-use doses in pour bottles or topical syringes. •Never withdraw a topical medication into a parenteral syringe and, conversely, do not place a solution intended for injection, such as a local anesthetic, into an open container. •Be sure that the word "topical" appears on any container holding a solution intended for topical use. •Keep local anesthetics for injection in their original vials until they are going to be used. Then withdraw the medication into a syringe and label it immediately. •And if possible, prepare pledgets of topical epinephrine before each procedure, which can eliminate the need for topical epinephrine in vials. FDA Patient Safety News: September 2009